Histopathology Study of the Platelet Rich Plasma on the Wound Healing in Rabbits

The study aimed to evaluate the beneficial effect of platelets rich plasma (PRP) on wound heal in rabbit.Eighteen healthy male adult rabbit were used they randomly divided into two equal groups (controlgroup 9, treated group 9). Under aseptic technique 3 cm skin incision was made back (dorsal) ofanimal by scalpel, after that sutured immediately silk suture materials 0.2 USP usedsimple interrupted receive post operation PRP (1ml) injected atthe site wound, while control left without treatment. Skin healing process follow up 1,2 and3 weeks histopathological examination, result display firstweek development granulation tissue with epithelial regeneration. 2 operationshow intense inflammatory infiltration desquamation tissue, and new blood vesselsformation. showed proliferation fibroblast deposition collagen, incontrol examination first week show infiltrate withdesquamated hemorrhage, area intensive acute inflammatoryinfiltrate, chronic debris giantcells, better than group.